The Columbia Valley AVA is an American Viticultural Area established in 1984 which lies in the Columbia River Plateau, through much of central and southern Washington state, with a small section crossing into the neighboring state of Oregon.

The AVA includes the drainage basin of the Columbia River and its tributaries through much of Washington. Horse Heaven Hills AVA, Rattlesnake Hills AVA, Red Mountain AVA, Wahluke Slope AVA, Walla Walla Valley AVA and Yakima Valley AVA are all within the Columbia Valley AVA.

Varietals grown here include Merlot, Riesling, Cabernet Sauvignon, Chenin Blanc, Sauvignon Blanc, and Sémillon. Concord grapes and other Vitis labrusca grapes are grown in the region as well.